How Much Vitamin C For Uti Treatment

How Much Vitamin C For Uti Treatment

Is taking vitamin C for UTI beneficial, harmful or neither? Vitamin C is a familiar dietary supplement for known reasons, however, the question of whether it can also treat UTI comes up often and should be addressed.

This article will mainly focus on the science behind vitamin C for UTI in terms of its potential to resolve symptoms. But we'll also briefly cover why it's important for sufferers of recurrent UTI to choose the right type of vitamin C supplement (if it's necessary at all).

Article Quick Links

• What do we know about vitamin C for UTI? >>>>
• The science for and against vitamin C for UTI >>>>
• Why you should think twice before taking vitamin C >>>>
• Is there any research to support vitamin C for UTI? >>>>
• How much vitamin C should you take for UTI? >>>>

Vitamin C made it into our list of the ten most searched UTI home remedies because it is recommended enthusiastically online.

But it's important to remember that this enthusiasm and its popularity doesn't necessarily mean it's effective. It's possible vitamin C may only be effective in some cases, by controlling symptoms and limiting infection, whilst not eliminating the pathogen causing recurrent urinary tract infections.

Often, the same people who recommend vitamin C online appear to still have symptoms that return time after time. That's something to think about.

"I've tried so many home remedies for UTIs. I was taking vitamin C for a few months and it seemed to help, but the symptoms always returned, so I eventually realized it really wasn't working!"

What Do We Know About Vitamin C For UTI?

For a start, we don't know enough. That's because there is a clear lack of studies into whether vitamin C for UTI treatment or prevention is beneficial.

Those studies that do exist mostly test vitamin C against a microorganism in vitro, that is, on the lab bench, and not in females with symptoms.

The largest study in humans we have found involved 110 pregnant women. Needless to say, many more rigorous studies are required with both pregnant and non-pregnant females, to provide a clearer picture of vitamin C's place as a potential UTI home remedy.

Vitamin C As An Essential Nutrient For Chronic Infection Support

Whether vitamin C can directly help treat or prevent UTI has little impact on its role as a crucial vitamin for bodily functions.

There is an established link between vitamin C and immune system function. While a healthy vitamin C intake is essential for fighting infection, we also know that for many with inflammation in the bladder, certain types of vitamin C supplements can trigger bladder symptoms.

In speaking with recurrent UTI specialists, the primary recommendation around supplemental vitamin C (if it is required) is that it should be taken in a buffered form, to minimize possible irritation.

"It's important to ensure any vitamin C is in a buffered form. One product I like for this purpose is Ultimate Protector. In addition to its potent antioxidant properties, Ultimate Protector activates Nrf2. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process as well as increased cysteine production (needed to make glutathione for detoxing). This is especially important for those who genetically tend to make more ammonia and less cysteine." Ruth Kriz, APRN, Chronic UTI and Interstitial Cystitis Expert

The Science Behind Vitamin C For UTI

Before we take a closer look at the research, let's talk about vitamin C's role in the body in general.

Vitamin C is an important part of a healthy diet as it plays a vital role in many areas of human physiology. It is essential for tissue health and wound healing, as it's necessary to make collagen, an important support protein.

Vitamin C is considered safe, even in the large doses often found in dietary supplements. This is because of its water solubility, which means it is readily eliminated from the body in the urine.

Because vitamin C makes it all the way to the urine, it's believed to have the ability to act directly on the pathogens that cause UTI. This is a key part of the theory.

Vitamin C May Cause The Death Of Certain Bacteria

Many of the bacterial species that cause UTIs are known to convert nitrate into another chemical called nitrite. You might recognise this if you've used urine dipstick tests (which aren't very accurate, by the way).

"I used to use those home urine dipstick tests but they always said I didn't have a UTI because there were no nitrites in my urine. I later found out that not all UTIs cause there to be nitrites present, so I stopped using them."

Nitrate can be ingested in the foods we eat, but it is also produced within our own bodies, so it's not something to worry about or try to avoid.

In an acidic environment, these "nitrate-reducing" bacteria take the nitrate found in our bodies and use it to produce nitric oxide, a very reactive chemical. The creation of this reactive nitric oxide also brings about their own death.

This is where vitamin C for UTI comes in. Vitamin C, also called "ascorbic acid," is believed to create an acidic environment, triggering the production of nitric oxide, and thereby causing the bacteria present to end their own existence.

Although this is pretty cool to think about – bacteria being responsible for their own death – UTIs are also caused by a variety of other microorganisms that are not nitrate reducing.

Many of these may show a different response to vitamin C, so without knowing which organism is causing your UTI, you can't be sure whether vitamin C will help or hinder.

The Problems With Vitamin C For UTI

You'll generally find that doctors can't promote vitamin C as a UTI remedy because of the limited evidence of the studies.

Whilst vitamin C is a natural chemical, it is still a chemical, like everything else, and its use may have unknown side effects.

Because we don't know exactly how taking vitamin C for UTI works, we also don't know if it is truly helping, or even how safe it is in the long term.

It is possible that vitamin C only attacks particular species of bacteria, and therefore may only help in some cases. In reality, we know very little about its effect on the many other microorganisms found in the urinary tract.

This is why it's so important to find out what's causing your UTI.

Because of these uncertainties, we don't know what the best dose of vitamin C is, nor how often it should be taken, let alone whether it works.

And when it comes to a chronic bladder infection, treatment with vitamin C may not be wise. Any potential benefit from the temporary relief of symptoms could be offset by other issues that arise.

What The Vitamin C Research Tells Us

Vitamin C studies:

1. In Vitro Evaluation of a New Treatment for Urinary Tract Infections Caused by Nitrate-Reducing Bacteria

2. Effects of pH, Nitrite, and Ascorbic Acid on Nonenzymatic Nitric Oxide Generation and Bacterial Growth in Urine

3. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy

4. The influence of some amino acids, vitamins and anti-inflammatory drugs on activity of chondroitinase produced by Proteus vulgaris caused urinary tract infection

What was tested:

• Whether the nitrate-reducing ability itself is necessary to bring about bacterial death. This was an in vitro study (not involving infection in human subjects).
• Whether the addition of vitamin C to nitrate-reducing bacteria kills them. This was an in vitro study.
• Whether vitamin C for urinary tract infection helps reduce symptoms and prevents positive results in urine culture tests, in pregnant women. This was done in real humans.
• Whether vitamin C enhances the ability of a bacterium to damage the protective chemicals found in the bladder wall. This was an in vitro study using live bacteria isolated from humans.

What was found:

• Nitrate-reducing bacteria were killed by the addition of vitamin C in vitro. Vitamin C made conditions more acidic, and this caused the production of nitric oxide. Nitric oxide caused the death of these bacteria. Mutant bacteria (their nitrate-reducing genes were absent) were not vulnerable to vitamin C/acid attack.
• Allowing the bacteria to grow in an acid-free, nitrate-rich environment before vitamin C was added, enhanced the killing.
• Vitamin C appeared to be effective in reducing symptoms and positive results in urine culture tests, in pregnant women.
• In one in vitro study, vitamin C appeared to increase the ability of a particular bacterium (Proteus vulgaris) to damage the bladder wall.

What you need to know:

• The nitric oxide generating mechanism is not yet proven to occur in humans who take vitamin C for UTI.
• Three species of bacteria (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus saprophyticus) were shown to be sensitive to vitamin C in the lab. At this point in time, there are no studies that indicate whether other microorganisms are also sensitive.
• It is encouraging that pregnant women responded to vitamin C with reduced symptoms and fewer positive urine tests. Although this was a moderately large study (110 women), this may not apply to non-pregnant females.
• The effect of vitamin C in enhancing the ability of Proteus vulgaris to damage the bladder wall has only been demonstrated in vitro. It is possible that vitamin C's overall effect, within the human body, would still be beneficial, because it tends to acidify the urine and Proteus vulgaris prefers a less acid pH.

Summary of the science:

• There is some evidence to suggest vitamin C may be an effective remedy for urinary tract infections involving nitrate-reducing bacteria.
• Urine with a high pH (alkaline), or any other reason to suspect a Proteus vulgaris infection, may make you consider avoiding vitamin C therapy.
• The research on vitamin C for UTI is still at its early stages.
• Larger, more rigorous, and better controlled studies are needed on pregnant and on non-pregnant females. These should assess if, how and when vitamin C for UTI is the right choice of therapy.

How Much Vitamin C Should You Take For UTI?

If you've read anything in this article, you'll already know the more important question is, 'Should I take vitamin C for UTI at all?'

But say you are going to give it a shot – maybe you've had testing that has identified nitrate-reducing bacteria, or maybe you've been advised to try it.

What do the studies tell us and what is a safe dosage of vitamin C?

First, let's take a look at how vitamin C the average person needs to stay healthy, then put it in the context of treatment.

Recommended Daily Intake Of Vitamin C

It's fairly common knowledge that vitamin C is essential in the human diet. A prolonged deficiency is otherwise known as 'scurvy.'

And no, scurvy is not limited to pirates and sailors, but it was way back in 1747 that James Lind deduced through a trial on sailors (who were very likely to suffer from it), that oranges and lemons treated this mysterious illness.

It wasn't until 1933 that the chemical structure for vitamin C was identified, and since then science has come a long way in discovering the benefits of it.

The National Academy of Sciences (USA) and the NIH suggest the following Recommended Daily Amount (RDA) of vitamin C in adult females:

Female Life Stage	RDA
Adult 19+	75 mg
Pregnant	85 mg
Breastfeeding	120 mg

Although scurvy is rarely seen today, it's best to ensure you're getting the amounts above at a minimum. And it's important to note that any recommended daily amount includes both food and supplement sources.

Doses Of Vitamin C For Scurvy

The British National Formulary (the "prescriber's bible") currently recommends at least 250 mg of vitamin C daily (in divided doses) to treat scurvy. The highest recommended daily dose to prevent scurvy in those at risk is only 75 mg.

Scurvy is a very simple condition to treat and to prevent; surprisingly little vitamin C is required to stave off symptoms. Antarctic explorers stranded over winter in the early 1900s derived sufficient vitamin C from the meat of the occasional seal they captured and ate. Most animal species are able to make their own vitamin C, humans are among the exceptions.

Mega Doses Of Vitamin C For Illness

You may have noticed that it's quite common to see vitamin C doses of 1 gram (1,000 mg) in supplements. While this is clearly way over the daily recommended minimum, it is still considered quite safe.

When it comes to using vitamin C as a therapy for specific illnesses, dosages used tend to be much higher. So far, research indicates that because vitamin C has low toxicity, it is unlikely to cause serious side effects up to a certain point.

The NIH sets Tolerable Upper Intake Levels (ULs) on vitamin C in females as follows:

Female Life Stage	RDA
Adult 19+	2000 mg
Pregnant	2000 mg
Breastfeeding	2000 mg

Safety of Vitamin C

The most comprehensive analysis on the safety issues concerned with taking vitamin C supplements was conducted by the National Academy of Sciences (USA) in 2000.

There were fears that dosages over an upper tolerable limit may enhance the risk of kidney stones, iron toxicity, vitamin B12 deficiency, copper deficiency, dental enamel erosion, and diarrhoea, amongst others.

They couldn't find a satisfactory link with most of these supposed side-effects, but they did conclude that high doses of vitamin C commonly cause diarrhoea. This side effect was used to set the upper limits in the table above.

Taking vitamin C to acidify the urine, for example, involves taking "mega doses" of the vitamin.

In the study in pregnant females we've linked to above, the prescribed dosage was 100 mg, which is well within the daily limit.

However, the prescribed dose for urinary acidification via the use of vitamin C for UTI often ranges from 4 to 12 grams of vitamin C daily. This is as much as 6 times the upper limit recommended, which makes the risk of diarrhoea as a side-effect a distinct possibility.

Taking vitamin C as a dietary supplement is, by and large, safe, but there are certain medical conditions for which medical advice should be sought before vitamin C supplements are started. For the higher doses involved in urinary acidification, medical advice becomes more important.

Vitamin C For UTI Quick Points

• Vitamin C shows promise as a therapy for urinary tract infections.
• Further research is needed to discover more precisely how it may work, how much you should take, and how to navigate the potential hazards identified above.
• Even if vitamin C for UTI is helpful for specific bacteria, it may make things worse for others.
• Vitamin C as a supplement is generally safe, but certain medical conditions and mega doses should first be discussed with your doctor.

Don't take our word for it, do your own research, and take a quick read of our UTI home remedies section for more information on how to go about it.

We've said it before, and we'll say it again… It's always a good idea to do a little background reading about a product you're thinking of taking – before you take it!

Research papers can look complicated at first glance, but you'll often find the abstract at the top of the paper will give you a good overview, and help you decide quickly whether you want to read it.

Sure, some of the concepts are complex, but you can find some super interesting and helpful information out there.

The (Not So) Final Word On Vitamin C For UTI

Many UTI sufferers swear by vitamin C as a treatment for UTIs. You'll see it recommended in forums, and natural remedies articles. This happens with many UTI home remedies.

But you should ask yourself, if vitamin C or other home remedies are so effective, why do their advocates keep getting urinary tract infections?

In truth, we don't know whether vitamin C helps for UTIs. This is because:

1) The evidence usually comes from studies done on how vitamin C affects microorganism directly, in the laboratory. Human studies typically involve a small number of sufferers or those who are pregnant.

2) The best dosage, best daily pattern for taking vitamin C has not yet been investigated.

3) We don't know which microorganisms vitamin C works against in humans, which it has no effect on, and for which type of infections, if any, vitamin C may make things worse.

What other remedies have you considered trying for UTIs?

To help you navigate your way through it all, we've put together a list of the ten most popular UTI remedies, along with the evidence to support or debunk each.

To get answers to commonly asked questions about chronic and recurrent UTI, visit our FAQ page . Share your questions and comments below, or get in touch with our team.

How Much Vitamin C For Uti Treatment

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